ABSTRACT:
Just when you thought it was safe to go into the water you find out that the sharks are still there. No, Proposition 65 has not gone away and companies are still being sued quietly and under the radar. You will be surprised at the data that has been collected for this presentation. New advances in chemical analysis technology instrumentation and methods have made it easier to find suspect chemicals in consumer products at levels not accessible before. Also, It is exceedingly easy to file lawsuits under Proposition 65. Learn about these new advances so that you can protect your company and your clients from Proposition 65 lawsuits. You will also learn how these new advances may affect your responsibilities under the newest California law SB 484. The presentation consists of two parts, the first dealing with interpretation of Prop 65 as it applies to cosmetics and the second provides practical illustrations of trace level contaminants/toxins detection utilizing the advanced instrumentation.

   
Bradford Rope is the president of BioScreen Testing Services, Inc. which he founded in 1985. BioScreen specializes in cGMP Analytical chemistry, microbiology and clinical studies for personal care and pharmaceutical companies. Brad has over 25 years of industry experience. Brad is a well regarded industry leader who has authored numerous articles and is a frequent speaker on personal care product technical issues.

Dr. Krishna Kallury, Ph.D. is a Senior Scientist at BioScreen Testing. He has been associated with the chromatographic science industry for the past 14 years and worked for leaders like Supelco, Agilent, Varian and Phenomenex at the Senior Chemist/R&D Manager level. Earlier, he was a staff/faculty member at the Department of Chemistry, University of Toronto, Canada, for 16 years. His achievements include over 100 publications in peer-reviewed journals, several U.S. and Canadian patents and pioneering applications in the GC, HPLC and SPE areas relating to pharmaceuticals, cosmetics and nutritional industries.

ABSTRACT:

Virtually every cosmetic ingredient and treatment has the ability to affect the human genome; some have very slight impact, others effect significant change. DNA microarray analysis permits us to assess an ingredient or product’s effects on thousands of genes at one time, revealing a “genetic signature” unique to the material. This knowledge  allows us the unprecedented ability to identify tens-to-thousands of research targets, screen potential toxicants and predict ingredient and product results in the skin – and potentially hair growth – in days instead of months or years.

DNA microarray technology is emerging as a powerful, versatile and relatively inexpensive investigative tool in such fields as pharmaceuticals, agriculture, ecotoxicology, food safety and nutraceuticals. Now making in-roads into cosmetic development laboratories, the technology employs a variety of human skin models – including keratinocyte, fibroblast, melanocyte and adipocyte cell groups – to determine a material’s impact on genetic markers, which then allows us to infer biological processes triggered in these cells. The resulting data can be applied in cosmetic, cosmeceutical and OTC areas of interest, such as:

Robert Holtz, President and CSO of BioInnovation Laboratories in Lakewood, Colorado, will take us on a journey into the world of DNA microarray analysis, focusing on its many applications in cosmetics. He will begin with a brief technological tutorial of DNA microarrays with an overview of those aspects of the technology most useful in cosmetic development and marketing data. Via case studies and other data, he will weigh the benefits and drawbacks of the technology, outline where in the product development cycle it is most helpful, identify appropriate models for specific areas of study, and provide a short discussion of how to interpret and weigh data.

Robert Holtz earned his B.S. from Colorado State University and his M.S. from Texas Christian University. While at TCU, his research aims focused on changes in blood biochemistry that occur immediately after intense exercise and also the long term biochemical and physiological changes that occur after different types of exercise training. After completion of his M.S. he joined a laboratory in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston. The research projects of this laboratory were aimed at mapping the process by which the heart became less responsive to stress with age and how this loss of response impacted the normal gene expression profile of the heart and lead to heart failure. After his work at the University of Houston, Robert Holtz brought his extensive training in cell culture and molecular biology to BioInnovation Laboratories, a testing laboratory in Lakewood, CO where he has the position of President and Chief Science Officer. His background in aging and gene expression research has been extremely beneficial to BioInnovation Laboratories and has facilitated his company in offering the powerful technology of DNA microarrays and other innovative methods to skin research in the Cosmetic and Personal Health Care industries.