April 2019 Meeting
TOPIC: Non-animal Test Methods for Eye Area Cosmetic and Personal Care Safety Assessment: History, Present and Future
This talk will focus on how to determine if cosmetics and personal care products are safe for eye area application. This will include a brief background and then a technical presentation which will include: current available test methods including procedures, application domains and accuracy. We also will discuss the regulatory landscape for testing including the move away from animal testing.
Dr Lebrun earned his BA in Biology at UC San Diego and PhD at UC Irvine in Toxicology as well as being a Research Fellow at both Stanford University in Immunology and Oncology and UC Berkeley in Cell and Molecular Biology. The major focus of his research has targeted methods development in the areas of biochemistry, immunology, toxicology, and molecular diagnostics. As part of this work, I have studied the ocular toxicology and biochemical mechanisms of a variety of diverse test systems, which include ex vivo bovine, chicken, and rabbit eye models, and other eye irritation tests including those conducted using hen eggs (HETCAM and CAMVA tests) and differentiated epithelial cells (EpiOcular, Short Time Exposure test, and our own cell-based eye test that is in early stages of development). Overall, these studies have led to the hypothesis that the extent and type of initial chemical injury caused by specific water-soluble and -insoluble macromolecules accurately predict ocular irritation responses. My current work in this area has focused on translating this understanding to the development of more predictive methods for assessing ocular irritation potential. Such advances will enable the more rapid testing of substances in terms of their identification as ocular corrosives and irritants. He has held teaching and research positions for Miragene in Irvine, Ca. and at Long Beach City College as well as at Cal State Fullerton from 2001 to 2011 and has been Founder and Principal at LeBrun Labs LLC since May 2009 and works with Bio Screen testing as well. While an undergraduate at the University of California – San Diego, he became interested in the mechanisms of vision and was accepted to participate in the honors thesis research program. Stewart subsequently published a scientific article on the temporal properties of short-wavelength photoreceptors (“blue cones”): Stockman, A., MacLeod, D.I., & Lebrun, S.J. (1993). Faster than the eye can see: Blue cones respond to rapid flicker. JOSA A, 10(6), 1396–1402.
TOPIC: 3D Printing Functional Materials & Devices
The ability to three-dimensionally interweave biological and functional materials could enable the creation of devices possessing unique and compelling geometries, properties, and functionalities. Indeed, interfacing active devices with biology in 3D could impact a variety of fields, including regenerative bioelectronics, smart prosthetics, biomedical devices, and human-machine interfaces. Biology, from the molecular scale of DNA and proteins, to the macroscopic scale of tissues and organs, is three-dimensional, often soft and stretchable, and temperature sensitive. This renders most biological platforms incompatible with the fabrication and materials processing methods that have been developed and optimized for functional electronics, which are typically planar, rigid and brittle. A number of strategies have been developed to overcome these dichotomies. Our approach is to use extrusion-based multi-material 3D printing, which is an additive manufacturing technology that offers freeform, autonomous fabrication. This approach addresses the dichotomies presented above by (1) using 3D printing and imaging for personalized, multifunctional device architectures; (2) employing ‘nano-inks’ as an enabling route for introducing diverse material functionality; and (3) 3D printing a range of functional inks to enable the interweaving of a diverse palette of materials, from biological to electronic. 3D printing is a multiscale platform, allowing for the incorporation of functional nanoscale inks, the printing of microscale features, and ultimately the creation of macroscale devices. This blending of 3D printing, functional materials, and ‘living’ platforms may enable next-generation 3D printed devices, from a one-pot printer.
Michael C. McAlpine is the Benjamin Mayhugh Associate Professor of Mechanical Engineering at the University of Minnesota (2015-Present). Previously, he was an Assistant Professor of Mechanical and Aerospace Engineering at Princeton University (2008-2015). He received a B.S. in Chemistry with honors from Brown University (2000), and an M.A. (2002) and Ph.D. (2006) in Chemistry from Harvard University. His current research is focused on 3D printing functional materials & devices. He has received a number of awards, including the George W. Taylor Award for Distinguished Research, the Presidential Early Career Award for Scientists and Engineers (PECASE), National Academy of Science (NAS) Kavli Frontiers Fellow, Extreme Mechanics Letters (EML) Young Investigator Award, SPIE Nanoengineering Pioneer Award, NIH Director’s New Innovator Award, Graduate Mentoring Award in Engineering, DARPA Young Faculty Award, National Academy of Engineering (NAE) - Frontiers of Engineering, Technology Review TR35 Young Innovator Under 35, DuPont Young Investigator Award, American Asthma Foundation Early Excellence Award, the Air Force Office of Scientific Research (AFOSR) Young Investigator Award, and the Intelligence Community (IC) Young Investigator Award.
|Event Date||April 23, 2019 5:00 pm|
|Event End Date||April 23, 2019 8:30 pm|